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Target
Nuclear receptor subfamily 2 group C member 2
Ligand
BDBM400813
Substrate
n/a
Meas. Tech.
Binding Assay
IC50
717±n/a nM
Citation
 Gray, N; Balk, S; Liu, Q; Chen, S Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof US Patent  US10000483 Publication Date 6/19/2018
Target
Name:
Nuclear receptor subfamily 2 group C member 2
Synonyms:
NR2C2 | NR2C2_HUMAN | Nuclear receptor subfamily 2 group C member 2 | Nuclear receptor subfamily 2 group C member 2 (TAK1) | TAK1 | TR4
Type:
PROTEIN
Mol. Mass.:
65411.75
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1476357
Residue:
596
Sequence:
MTSPSPRIQIISTDSAVASPQRIQIVTDQQTGQKIQIVTAVDASGSPKQQFILTSPDGAGTGKVILASPETSSAKQLIFTTSDNLVPGRIQIVTDSASVERLLGKTDVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKHHRNRCQFCRLKKCLEMGMKMESVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVADKDGARQTGLLDPGMLVNIQQPLIREDGTVLLATDSKAETSQGALGTLANVVTSLANLSESLNNGDTSEIQPEDQSASEITRAFDTLAKALNTTDSSSSPSLADGIDTSGGGSIHVISRDQSTPIIEVEGPLLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSLSTILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMAKLDIDGYEYAYLKAIVLFSPDHPGLTSTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPALRLMSSNITEELFFTGLIGNVSIDSIIPYILKMETAEYNGQITGASL
  
Inhibitor
Name:
BDBM400813
Synonyms:
QL-X-138 | US10000483, Compound II-6
Type:
Small organic molecule
Emp. Form.:
C25H19N5O2
Mol. Mass.:
421.4507
SMILES:
Cc1ccc(cc1NC(=O)C=C)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1cn[nH]c1
Structure:
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