Reaction Details 
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Interleukin-1 receptor-associated kinase 4
Ligand
BDBM402987
Substrate
n/a
Meas. Tech.
IRAK4 Enzymatic DELFIA Assay, Protocol A
IC50
1.000±n/a nM
Citation
Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Bicyclic-fused heteroaryl or aryl compounds US Patent US10329302 Publication Date 6/25/2019More Info.:
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
Inhibitor
Name:
BDBM402987
Synonyms:
US10329302, Example 134 | US10793579, Example 134 | US11702424, Example 134
Type:
Small organic molecule
Emp. Form.:
C19H22FN3O4
Mol. Mass.:
375.3941
SMILES:
CC(C)Oc1cc2c(OC[C@@H]3C[C@](C)(F)C(=O)N3)nccc2cc1C(N)=O |r|
Structure:
