Reaction Details  Report a problem with these data
Target
Bcl-2-related protein A1
Ligand
BDBM39171
Substrate
n/a
Meas. Tech.
TR-FRET secondary assay for HTS discovery of chemical inhibitors of anti-apoptotic protein Bfl-1
IC50
2290±220 nM
Citation
 PubChem, PC TR-FRET secondary assay for HTS discovery of chemical inhibitors of anti-apoptotic protein Bfl-1 PubChem Bioassay (2008)[AID]
Target
Name:
Bcl-2-related protein A1
Synonyms:
A1 | A1-A | B-cell leukemia/lymphoma 2 related protein A1a | B2LA1_MOUSE | Bcl2a1 | Bcl2a1a | Bfl-1 | Bfl1 | Hemopoietic-specific early response protein | Protein BFL-1
Type:
Apoptosis regulator protein
Mol. Mass.:
19909.74
Organism:
Mus musculus (Mouse)
Description:
gi_11024684
Residue:
172
Sequence:
MAESELMHIHSLAEHYLQYVLQVPAFESAPSQACRVLQRVAFSVQKEVEKNLKSYLDDFHVESIDTARIIFNQVMEKEFEDGIINWGRIVTIFAFGGVLLKKLPQEQIALDVCAYKQVSSFVAEFIMNNTGEWIRQNGGWEDGFIKKFEPKSGWLTFLQMTGQIWEMLFLLK
  
Inhibitor
Name:
BDBM39171
Synonyms:
3-chloranyl-4-morpholin-4-yl-1-(4-nitrophenyl)pyrrole-2,5-dione | 3-chloro-4-(4-morpholinyl)-1-(4-nitrophenyl)pyrrole-2,5-dione | 3-chloro-4-morpholin-4-yl-1-(4-nitrophenyl)pyrrole-2,5-dione | 3-chloro-4-morpholino-1-(4-nitrophenyl)-3-pyrroline-2,5-quinone | MLS-0111723.0001 | cid_16654752
Type:
Small organic molecule
Emp. Form.:
C14H12ClN3O5
Mol. Mass.:
337.715
SMILES:
[O-][N+](=O)c1ccc(cc1)N1C(=O)C(Cl)=C(N2CCOCC2)C1=O |t:14|
Structure:
Search PDB for entries with ligand similarity: