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Target
Isoform 2 of Nuclear receptor ROR-alpha (Alpha-2)
Ligand
BDBM39516
Substrate
n/a
Meas. Tech.
Dose-response cell-based assay for activators of the Retinoic Acid Receptor-related orphan receptor A (RORA)
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose-response cell-based assay for activators of the Retinoic Acid Receptor-related orphan receptor A (RORA) PubChem Bioassay (2007)[AID]
Target
Name:
Isoform 2 of Nuclear receptor ROR-alpha (Alpha-2)
Synonyms:
NR1F1 | Nuclear receptor ROR-alpha | Nuclear receptor ROR-alpha (Alpha-2) | Nuclear receptor ROR-alpha (Retinoid-related orphan receptor-alpha) (Nuclear receptor RZR-alpha). | RORA | RORA_HUMAN | RZRA
Type:
PROTEIN
Mol. Mass.:
63033.59
Organism:
Homo sapiens (Human)
Description:
EBI_101591
Residue:
556
Sequence:
MNEGAPGDSDLETEARVPWSIMGHCLRTGQARMSATPTPAGEGARRDELFGILQILHQCILSSGDAFVLTGVCCSWRQNGKPPYSQKEDKEVQTGYMNAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
  
Inhibitor
Name:
BDBM39516
Synonyms:
(1,1-Dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-yl)-(5-ethyl-[1,3,4]thiadiazol-2-yl)-amine | (1,1-diketo-1,2-benzothiazol-3-yl)-(5-ethyl-1,3,4-thiadiazol-2-yl)amine | MLS000031714 | N-(5-ethyl-1,3,4-thiadiazol-2-yl)-1,1-bis(oxidanylidene)-1,2-benzothiazol-3-amine | N-(5-ethyl-1,3,4-thiadiazol-2-yl)-1,1-dioxo-1,2-benzothiazol-3-amine | SMR000012882 | cid_626230
Type:
Small organic molecule
Emp. Form.:
C11H10N4O2S2
Mol. Mass.:
294.353
SMILES:
CCc1nnc(N=C2NS(=O)(=O)c3ccccc23)s1 |w:6.5|
Structure:
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