Reaction Details  Report a problem with these data
Target
Isoform 2 of Nuclear receptor ROR-alpha (Alpha-2)
Ligand
BDBM39563
Substrate
n/a
Meas. Tech.
Dose-response cell-based assay for activators of the Retinoic Acid Receptor-related orphan receptor A (RORA)
EC50
>3667±n/a nM
Citation
 PubChem, PC Dose-response cell-based assay for activators of the Retinoic Acid Receptor-related orphan receptor A (RORA) PubChem Bioassay (2007)[AID]
Target
Name:
Isoform 2 of Nuclear receptor ROR-alpha (Alpha-2)
Synonyms:
NR1F1 | Nuclear receptor ROR-alpha | Nuclear receptor ROR-alpha (Alpha-2) | Nuclear receptor ROR-alpha (Retinoid-related orphan receptor-alpha) (Nuclear receptor RZR-alpha). | RORA | RORA_HUMAN | RZRA
Type:
PROTEIN
Mol. Mass.:
63033.59
Organism:
Homo sapiens (Human)
Description:
EBI_101591
Residue:
556
Sequence:
MNEGAPGDSDLETEARVPWSIMGHCLRTGQARMSATPTPAGEGARRDELFGILQILHQCILSSGDAFVLTGVCCSWRQNGKPPYSQKEDKEVQTGYMNAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
  
Inhibitor
Name:
BDBM39563
Synonyms:
MLS000119552 | SMR000096473 | [1-(6-ethoxy-1,3-benzothiazol-2-yl)-4-piperidinyl]-[4-(2-pyridinyl)-1-piperazinyl]methanone | [1-(6-ethoxy-1,3-benzothiazol-2-yl)-4-piperidyl]-[4-(2-pyridyl)piperazino]methanone | [1-(6-ethoxy-1,3-benzothiazol-2-yl)piperidin-4-yl]-(4-pyridin-2-ylpiperazin-1-yl)methanone | cid_5309731
Type:
Small organic molecule
Emp. Form.:
C24H29N5O2S
Mol. Mass.:
451.584
SMILES:
CCOc1ccc2nc(sc2c1)N1CCC(CC1)C(=O)N1CCN(CC1)c1ccccn1
Structure:
Search PDB for entries with ligand similarity: