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Target
Serine/threonine-protein kinase PLK1
Ligand
BDBM41776
Substrate
n/a
Meas. Tech.
Concentration Response Redox Cycling H2O2 Generation assay to characterize small molecule inhibitors identified in the Polo box domain (PBD) of Plk1 Primary HTS.
EC50
>50000±n/a nM
Citation
 PubChem, PC Concentration Response Redox Cycling H2O2 Generation assay to characterize small molecule inhibitors identified in the Polo box domain (PBD) of Plk1 Primary HTS. PubChem Bioassay (2007)[AID]
Target
Name:
Serine/threonine-protein kinase PLK1
Synonyms:
PLK | PLK-1 | PLK1 | PLK1_HUMAN | Polo-like kinase 1 (PlK1) | Polo-like kinase 1 (Plk-1) | STPK13 | Serine/threonine-protein kinase (PLK1) | Serine/threonine-protein kinase 13 | polo-like kinase
Type:
Serine/threonine-protein kinase
Mol. Mass.:
68277.16
Organism:
Homo sapiens (Human)
Description:
P53350
Residue:
603
Sequence:
MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS
  
Inhibitor
Name:
BDBM41776
Synonyms:
3-ethyl-6-[4-(4-methoxyphenyl)piperazin-1-yl]carbonyl-5-methyl-thieno[2,3-d]pyrimidin-4-one | 3-ethyl-6-[4-(4-methoxyphenyl)piperazine-1-carbonyl]-5-methyl-thieno[2,3-d]pyrimidin-4-one | 3-ethyl-6-[4-(4-methoxyphenyl)piperazine-1-carbonyl]-5-methylthieno[2,3-d]pyrimidin-4-one | 3-ethyl-6-[[4-(4-methoxyphenyl)-1-piperazinyl]-oxomethyl]-5-methyl-4-thieno[2,3-d]pyrimidinone | 3-ethyl-6-{[4-(4-methoxyphenyl)piperazin-1-yl]carbonyl}-5-methylthieno[2,3-d]pyrimidin-4(3H)-one | MLS000089815 | SMR000024433 | cid_3241114
Type:
Small organic molecule
Emp. Form.:
C21H24N4O3S
Mol. Mass.:
412.505
SMILES:
CCn1cnc2sc(C(=O)N3CCN(CC3)c3ccc(OC)cc3)c(C)c2c1=O
Structure:
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