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Target
Muscarinic acetylcholine receptor M4
Ligand
BDBM48068
Substrate
n/a
Meas. Tech.
Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator(PAM): Analog Potency
EC50
2580±n/a nM
Citation
 PubChem, PC Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator(PAM): Analog Potency PubChem Bioassay (2010)[AID]
Target
Name:
Muscarinic acetylcholine receptor M4
Synonyms:
ACM4_RAT | Cholinergic, muscarinic M4 | Chrm-4 | Chrm4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52841.70
Organism:
RAT
Description:
Cholinergic, muscarinic M4 CHRM4 RAT::P08485
Residue:
477
Sequence:
MNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSATQNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
  
Inhibitor
Name:
BDBM48068
Synonyms:
3-amino-6-[3-(dimethylamino)propoxy]-4-methyl-N-(3-oxetanyl)-2-thieno[2,3-b]pyridinecarboxamide | 3-amino-6-[3-(dimethylamino)propoxy]-4-methyl-N-(oxetan-3-yl)thieno[2,3-b]pyridine-2-carboxamide | 3-azanyl-6-[3-(dimethylamino)propoxy]-4-methyl-N-(oxetan-3-yl)thieno[2,3-b]pyridine-2-carboxamide | VU0359439 | cid_45142477
Type:
Small organic molecule
Emp. Form.:
C17H24N4O3S
Mol. Mass.:
364.462
SMILES:
CN(C)CCCOc1cc(C)c2c(N)c(sc2n1)C(=O)NC1COC1
Structure:
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