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Target
Genome polyprotein
Ligand
BDBM55039
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay for inhibitors of the Hepatitis C Virus non-structural protein 3 helicase (NS3).
IC50
3018±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay for inhibitors of the Hepatitis C Virus non-structural protein 3 helicase (NS3). PubChem Bioassay (2009)[AID]
Target
Name:
Genome polyprotein
Synonyms:
NS3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
67067.41
Organism:
Hepatitis C virus
Description:
gi_125541954
Residue:
631
Sequence:
APITAYAQQTRGLLGCIITGLTGRDKNQVEGEVQIVSTAAQTFLATCINGVCWTVYHGAGTRTIASSKGPVIQMYTNVDQDLVGWPAPQGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDGRGSLLSPRPISYLKGSSGGPLLCPAGHAVGIFRAAVCTRGVAKAVDFIPVEGLETTMRSPVFSDNSSPPAVPQSYQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGIDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGSAYDIIICDECHSTDATSILGIGTVLDQAETAGARLTVLATATPPGSVTVPHPNIEEVALSTTGEIPFYGKAIPLEAIKGGRHLIFCHSKKKCDELAAKLVALGVNAVAYYRGLDVSVIPASGDVVVVATDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVTPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQSGENLPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEITLTHPITKYIMTCMSADLEVVT
  
Inhibitor
Name:
BDBM55039
Synonyms:
1-(6-methylpyridin-2-yl)-4-oxidanyl-2-(3-phenoxyphenyl)-3-thiophen-2-ylcarbonyl-2H-pyrrol-5-one | 3-Hydroxy-1-(6-methyl-pyridin-2-yl)-5-(3-phenoxy-phenyl)-4-(thiophene-2-carbonyl)-1,5-dihydro-pyrrol-2- one | 3-hydroxy-1-(6-methyl-2-pyridyl)-5-(3-phenoxyphenyl)-4-(2-thenoyl)-3-pyrrolin-2-one | 4-hydroxy-1-(6-methyl-2-pyridinyl)-3-[oxo(thiophen-2-yl)methyl]-2-(3-phenoxyphenyl)-2H-pyrrol-5-one | 4-hydroxy-1-(6-methylpyridin-2-yl)-2-(3-phenoxyphenyl)-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one | MLS001029613 | SMR000425062 | cid_3303130
Type:
Small organic molecule
Emp. Form.:
C27H20N2O4S
Mol. Mass.:
468.524
SMILES:
Cc1cccc(n1)N1C(C(C(=O)c2cccs2)C(=O)C1=O)c1cccc(Oc2ccccc2)c1
Structure:
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