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Target
Tumor necrosis factor
Ligand
BDBM54495
Substrate
n/a
Meas. Tech.
SAR analysis of inhibitors of TNFa specific NF-kB induction revised
IC50
952±n/a nM
Citation
 PubChem, PC SAR analysis of inhibitors of TNFa specific NF-kB induction revised PubChem Bioassay (2010)[AID]
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM54495
Synonyms:
4-tert-butylbenzoic acid [(Z)-[amino(2-pyridinyl)methylidene]amino] ester | 4-tert-butylbenzoic acid [(Z)-[amino(2-pyridyl)methylene]amino] ester | MLS001229555 | SMR000611624 | The compound has not trivial name. | [(Z)-[amino(pyridin-2-yl)methylidene]amino] 4-tert-butylbenzoate | [(Z)-[azanyl(pyridin-2-yl)methylidene]amino] 4-tert-butylbenzoate | cid_9566902
Type:
Small organic molecule
Emp. Form.:
C17H19N3O2
Mol. Mass.:
297.3517
SMILES:
CC(C)(C)c1ccc(cc1)C(=O)ON=C(N)c1ccccn1 |w:13.13|
Structure:
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