Reaction Details  Report a problem with these data
Target
Tumor necrosis factor
Ligand
BDBM62273
Substrate
n/a
Meas. Tech.
SAR analysis of inhibitors of TNFa specific NF-kB induction revised
IC50
70.6±n/a nM
Citation
 PubChem, PC SAR analysis of inhibitors of TNFa specific NF-kB induction revised PubChem Bioassay (2010)[AID]
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM62273
Synonyms:
2,4-dimethylbenzoic acid [(Z)-[amino(2-pyridinyl)methylidene]amino] ester | 2,4-dimethylbenzoic acid [(Z)-[amino(2-pyridyl)methylene]amino] ester | MLS-0379504.0001 | [(Z)-[amino(pyridin-2-yl)methylidene]amino] 2,4-dimethylbenzoate | [(Z)-[azanyl(pyridin-2-yl)methylidene]amino] 2,4-dimethylbenzoate | cid_9587731
Type:
Small organic molecule
Emp. Form.:
C15H15N3O2
Mol. Mass.:
269.2985
SMILES:
Cc1ccc(C(=O)ON=C(N)c2ccccn2)c(C)c1 |w:8.7|
Structure:
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