Reaction Details  Report a problem with these data
Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM73190
Substrate
n/a
Meas. Tech.
SAR analysis for the identification of translation initiation inhibitors (eIF4H)
IC50
84400±n/a nM
Citation
 PubChem, PC SAR analysis for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2010)[AID]
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM73190
Synonyms:
2-[6-(furan-2-yl)pyridazin-3-yl]sulfanyl-N-phenyl-ethanamide | 2-[6-(furan-2-yl)pyridazin-3-yl]sulfanyl-N-phenylacetamide | 2-[[6-(2-furanyl)-3-pyridazinyl]thio]-N-phenylacetamide | 2-[[6-(2-furyl)pyridazin-3-yl]thio]-N-phenyl-acetamide | MLS-0241346.0001 | cid_7207110
Type:
Small organic molecule
Emp. Form.:
C16H13N3O2S
Mol. Mass.:
311.358
SMILES:
O=C(CSc1ccc(nn1)-c1ccco1)Nc1ccccc1
Structure:
Search PDB for entries with ligand similarity: