Reaction Details  Report a problem with these data
Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM73198
Substrate
n/a
Meas. Tech.
SAR analysis for the identification of translation initiation inhibitors (eIF4H)
IC50
44500±n/a nM
Citation
 PubChem, PC SAR analysis for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2010)[AID]
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM73198
Synonyms:
MLS-0205969.0001 | N-(4-fluorophenyl)-2-(1-methyl-3-phenylsulfanyl-indol-2-yl)ethanamide | N-(4-fluorophenyl)-2-(1-methyl-3-phenylsulfanylindol-2-yl)acetamide | N-(4-fluorophenyl)-2-[1-methyl-3-(phenylthio)-2-indolyl]acetamide | N-(4-fluorophenyl)-2-[1-methyl-3-(phenylthio)indol-2-yl]acetamide | cid_1958202
Type:
Small organic molecule
Emp. Form.:
C23H19FN2OS
Mol. Mass.:
390.473
SMILES:
Cn1c(CC(=O)Nc2ccc(F)cc2)c(Sc2ccccc2)c2ccccc12
Structure:
Search PDB for entries with ligand similarity: