Reaction Details  Report a problem with these data
Target
Ubiquitin-conjugating enzyme E2 N
Ligand
BDBM78703
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay
IC50
12263±510 nM
Citation
 PubChem, PC Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay PubChem Bioassay (2011)[AID]
Target
Name:
Ubiquitin-conjugating enzyme E2 N
Synonyms:
BLU | UBE2N | UBE2N_HUMAN | ubiquitin-conjugating enzyme E2 N
Type:
PROTEIN
Mol. Mass.:
17137.61
Organism:
Homo sapiens (Human)
Description:
EBI_101440
Residue:
152
Sequence:
MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLELFLPEEYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDPLANDVAEQWKTNEAQAIETARAWTRLYAMNNI
  
Inhibitor
Name:
BDBM78703
Synonyms:
(2S)-2-[4-[(1R)-1-amino-2-hydroxy-ethyl]triazol-1-yl]-3-(1H-indol-2-yl)-1-piperazino-propan-1-one;hydrochloride | (2S)-2-[4-[(1R)-1-amino-2-hydroxyethyl]-1-triazolyl]-3-(1H-indol-2-yl)-1-(1-piperazinyl)-1-propanone;hydrochloride | (2S)-2-[4-[(1R)-1-amino-2-hydroxyethyl]triazol-1-yl]-3-(1H-indol-2-yl)-1-piperazin-1-ylpropan-1-one;hydrochloride | (2S)-2-[4-[(1R)-1-azanyl-2-oxidanyl-ethyl]-1,2,3-triazol-1-yl]-3-(1H-indol-2-yl)-1-piperazin-1-yl-propan-1-one;hydrochloride | CD-MONO-SW-DP | MLS000560545 | SMR000327458 | cid_16129541
Type:
Small organic molecule
Emp. Form.:
C19H25N7O2
Mol. Mass.:
383.4475
SMILES:
N[C@@H](CO)c1cn(nn1)[C@@H](Cc1cc2ccccc2[nH]1)C(=O)N1CCNCC1
Structure:
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