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Target
Sentrin-specific protease 8
Ligand
BDBM76519
Substrate
n/a
Meas. Tech.
SAR Analysis of small molecule inhibitors of Sentrin-specific protease 8 (SENP8) using a Luminescent assay - Set 2
IC50
43000±n/a nM
Citation
 PubChem, PC SAR Analysis of small molecule inhibitors of Sentrin-specific protease 8 (SENP8) using a Luminescent assay - Set 2 PubChem Bioassay (2011)[AID]
Target
Name:
Sentrin-specific protease 8
Synonyms:
DEN1 | NEDP1 | PRSC2 | SENP8 | SENP8_HUMAN | SUMO/sentrin specific peptidase family member 8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
24104.52
Organism:
Homo sapiens (Human)
Description:
gi_262118306
Residue:
212
Sequence:
MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQFIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFRQQTESLLQLLTPAYITKKRGEWKDLITTLAKK
  
Inhibitor
Name:
BDBM76519
Synonyms:
(6E)-6-[(2E)-2-[(5Z)-5-(6-ketocyclohexa-2,4-dien-1-ylidene)-1,2,4-oxadiazolidin-3-ylidene]ethylidene]cyclohexa-2,4-dien-1-one | (6E)-6-[(2E)-2-[(5Z)-5-(6-oxidanylidenecyclohexa-2,4-dien-1-ylidene)-1,2,4-oxadiazolidin-3-ylidene]ethylidene]cyclohexa-2,4-dien-1-one | (6E)-6-[(2E)-2-[(5Z)-5-(6-oxo-1-cyclohexa-2,4-dienylidene)-1,2,4-oxadiazolidin-3-ylidene]ethylidene]-1-cyclohexa-2,4-dienone | (6E)-6-[(2E)-2-[(5Z)-5-(6-oxocyclohexa-2,4-dien-1-ylidene)-1,2,4-oxadiazolidin-3-ylidene]ethylidene]cyclohexa-2,4-dien-1-one | 2-{2-[5-(2-hydroxyphenyl)-1,2,4-oxadiazol-3-yl]vinyl}phenol | MLS000626734 | SMR000299118 | cid_16188892
Type:
Small organic molecule
Emp. Form.:
C16H12N2O3
Mol. Mass.:
280.2781
SMILES:
Oc1ccccc1C=Cc1noc(n1)-c1ccccc1O |w:8.9|
Structure:
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