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Target
Apoptosis regulator Bcl-2
Ligand
BDBM50239079
Substrate
n/a
Meas. Tech.
ChEMBL_1665216 (CHEMBL4015012)
Ki
470±n/a nM
Citation
 Luan, S; Ge, Q; Chen, Y; Dai, M; Yang, J; Li, K; Liu, D; Zhao, L Discovery and structure-activity relationship studies of N-substituted indole derivatives as novel Mcl-1 inhibitors. Bioorg Med Chem Lett 27:1943-1948 (2017) [PubMed]  Article
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50239079
Synonyms:
CHEMBL4070752
Type:
Small organic molecule
Emp. Form.:
C29H31NO4
Mol. Mass.:
457.5607
SMILES:
CC(C)(C)c1ccc(OCCCn2ccc3cc(OCc4cccc(c4)C(O)=O)ccc23)cc1
Structure:
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