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Target
Histone deacetylase 1
Ligand
BDBM50239859
Substrate
n/a
Meas. Tech.
ChEMBL_1667343 (CHEMBL4017139)
IC50
77±n/a nM
Citation
 Stenzel, K; Hamacher, A; Hansen, FK; Gertzen, CGW; Senger, J; Marquardt, V; Marek, L; Marek, M; Romier, C; Remke, M; Jung, M; Gohlke, H; Kassack, MU; Kurz, T Alkoxyurea-Based Histone Deacetylase Inhibitors Increase Cisplatin Potency in Chemoresistant Cancer Cell Lines. J Med Chem 60:5334-5348 (2017) [PubMed]  Article
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50239859
Synonyms:
CHEMBL4088276
Type:
Small organic molecule
Emp. Form.:
C18H24N4O5
Mol. Mass.:
376.407
SMILES:
COc1cc(NC(=O)NOCCCCCC(=O)NO)c2nccc(C)c2c1
Structure:
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