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Target
Polycomb protein EED
Ligand
BDBM50241649
Substrate
n/a
Meas. Tech.
ChEMBL_1670151 (CHEMBL4020039)
Ki
450±n/a nM
Citation
 Wang, Y; Edalji, RP; Panchal, SC; Sun, C; Djuric, SW; Vasudevan, A Are We There Yet? Applying Thermodynamic and Kinetic Profiling on Embryonic Ectoderm Development (EED) Hit-to-Lead Program. J Med Chem 60:8321-8335 (2017) [PubMed]  Article
Target
Name:
Polycomb protein EED
Synonyms:
EED | EED_HUMAN | WAIT-1 | WD protein associating with integrin cytoplasmic tails 1 | hEED
Type:
Protein
Mol. Mass.:
50201.68
Organism:
Homo sapiens (Human)
Description:
O75530
Residue:
441
Sequence:
MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR
  
Inhibitor
Name:
BDBM50241649
Synonyms:
CHEMBL4093134
Type:
Small organic molecule
Emp. Form.:
C18H21BrFN3
Mol. Mass.:
378.282
SMILES:
CN(C)[C@H]1CN(Cc2c(F)cccc2Br)C[C@@H]1c1ccccn1 |r|
Structure:
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