Reaction Details 
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Free fatty acid receptor 1
Ligand
BDBM50244003
Substrate
n/a
Meas. Tech.
ChEMBL_1673100 (CHEMBL4023129)
EC50
2550±n/a nM
Citation
Shi, J; Gu, Z; Jurica, EA; Wu, X; Haque, LE; Williams, KN; Hernandez, AS; Hong, Z; Gao, Q; Dabros, M; Davulcu, AH; Mathur, A; Rampulla, RA; Gupta, AK; Jayaram, R; Apedo, A; Moore, DB; Liu, H; Kunselman, LK; Brady, EJ; Wilkes, JJ; Zinker, BA; Cai, H; Shu, YZ; Sun, Q; Dierks, EA; Foster, KA; Xu, C; Wang, T; Panemangalore, R; Cvijic, ME; Xie, C; Cao, GG; Zhou, M; Krupinski, J; Whaley, JM; Robl, JA; Ewing, WR; Ellsworth, BA Discovery of Potent and Orally Bioavailable Dihydropyrazole GPR40 Agonists. J Med Chem 61:681-694 (2018) [PubMed] ArticleMore Info.:
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
Inhibitor
Name:
BDBM50244003
Synonyms:
CHEMBL4067111
Type:
Small organic molecule
Emp. Form.:
C24H25F4N3O3
Mol. Mass.:
479.4672
SMILES:
C[C@H]1[C@H](CC(O)=O)N(N=C1C(F)(F)F)c1ccc(OC2CCN(CC2)c2ccc(F)cc2)cc1 |r,c:8|
Structure:
