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Target
Protein arginine N-methyltransferase 1
Ligand
BDBM50245959
Substrate
n/a
Meas. Tech.
ChEMBL_1676351 (CHEMBL4026494)
IC50
3000±n/a nM
Citation
 Wang, C; Jiang, H; Jin, J; Xie, Y; Chen, Z; Zhang, H; Lian, F; Liu, YC; Zhang, C; Ding, H; Chen, S; Zhang, N; Zhang, Y; Jiang, H; Chen, K; Ye, F; Yao, Z; Luo, C Development of Potent Type I Protein Arginine Methyltransferase (PRMT) Inhibitors of Leukemia Cell Proliferation. J Med Chem 60:8888-8905 (2017) [PubMed]  Article
Target
Name:
Protein arginine N-methyltransferase 1
Synonyms:
ANM1_RAT | Histone-arginine N-methyltransferase PRMT1 | Hrmt1l2 | Prmt1
Type:
PROTEIN
Mol. Mass.:
40514.94
Organism:
Rattus norvegicus
Description:
ChEMBL_103589
Residue:
353
Sequence:
MAAAEAANCIMEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLHARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
  
Inhibitor
Name:
BDBM50245959
Synonyms:
CHEMBL1617447
Type:
Small organic molecule
Emp. Form.:
C22H26N2S
Mol. Mass.:
350.52
SMILES:
CN(C)CCN(C)Cc1ccccc1Sc1cccc2ccccc12
Structure:
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