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Target
Macrophage metalloelastase
Ligand
BDBM50246196
Substrate
n/a
Meas. Tech.
ChEMBL_1676601 (CHEMBL4026744)
Kd
875000±n/a nM
Citation
 Fragai, M; Comito, G; Di Cesare Mannelli, L; Gualdani, R; Calderone, V; Louka, A; Richichi, B; Francesconi, O; Angeli, A; Nocentini, A; Gratteri, P; Chiarugi, P; Ghelardini, C; Tadini-Buoninsegni, F; Supuran, CT; Nativi, C Lipoyl-Homotaurine Derivative (ADM_12) Reverts Oxaliplatin-Induced Neuropathy and Reduces Cancer Cells Malignancy by Inhibiting Carbonic Anhydrase IX (CAIX). J Med Chem 60:9003-9011 (2017) [PubMed]  Article
Target
Name:
Macrophage metalloelastase
Synonyms:
HME | MMP12 | MMP12_HUMAN | Matrix metalloproteinase 12 | Matrix metalloproteinase-12 (MMP 12) | Matrix metalloproteinase-12 (MMP-12) | Matrix metalloproteinase-12 (MMP12) | Matrix metalloproteinases 12 (MMP-12)
Type:
Enzyme
Mol. Mass.:
54012.99
Organism:
Homo sapiens (Human)
Description:
P39900
Residue:
470
Sequence:
MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLMKEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFFFKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRPEPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITKNFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
  
Inhibitor
Name:
BDBM50246196
Synonyms:
CHEMBL4065195
Type:
Small organic molecule
Emp. Form.:
C11H20NNaO4S3
Mol. Mass.:
349.466
SMILES:
[Na+].[O-]S(=O)(=O)CCCNC(=O)CCCCC1CCSS1
Structure:
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