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Target
Melanocortin receptor 4
Ligand
BDBM50247165
Substrate
n/a
Meas. Tech.
ChEMBL_1677402 (CHEMBL4027545)
EC50
562±n/a nM
Citation
 Hamdouchi, C; Maiti, P; Warshawsky, AM; DeBaillie, AC; Otto, KA; Wilbur, KL; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Cr, S; Lineswala, JP; Neathery, GL; Bouaichi, C; Diseroad, BA; Campbell, AN; Sweetana, SA; Adams, LA; Cabrera, O; Ma, X; Yumibe, NP; Montrose-Rafizadeh, C; Chen, Y; Miller, AR Discovery of LY3104607: A Potent and Selective G Protein-Coupled Receptor 40 (GPR40) Agonist with Optimized Pharmacokinetic Properties to Support Once Daily Oral Treatment in Patients with Type 2 Diabetes Mellitus. J Med Chem 61:934-945 (2018) [PubMed]  Article
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R_RAT | Mc4r
Type:
PROTEIN
Mol. Mass.:
36892.87
Organism:
Rattus norvegicus
Description:
ChEMBL_11005
Residue:
332
Sequence:
MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY
  
Inhibitor
Name:
BDBM50247165
Synonyms:
CHEMBL4077366
Type:
Small organic molecule
Emp. Form.:
C28H27N3O5
Mol. Mass.:
485.5311
SMILES:
COCCOc1ccc(cc1)-c1nc2ccc(COc3ccc(cc3)[C@H](CC(O)=O)C#CC)cn2n1 |r|
Structure:
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