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Target
Protein arginine N-methyltransferase 3
Ligand
BDBM50247363
Substrate
n/a
Meas. Tech.
ChEMBL_1677669 (CHEMBL4027812)
IC50
46±n/a nM
Citation
 Kaniskan, HÜ; Eram, MS; Zhao, K; Szewczyk, MM; Yang, X; Schmidt, K; Luo, X; Xiao, S; Dai, M; He, F; Zang, I; Lin, Y; Li, F; Dobrovetsky, E; Smil, D; Min, SJ; Lin-Jones, J; Schapira, M; Atadja, P; Li, E; Barsyte-Lovejoy, D; Arrowsmith, CH; Brown, PJ; Liu, F; Yu, Z; Vedadi, M; Jin, J Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3). J Med Chem 61:1204-1217 (2018) [PubMed]  Article
Target
Name:
Protein arginine N-methyltransferase 3
Synonyms:
2.1.1.- | ANM3_HUMAN | HRMT1L3 | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3 | PRMT3 | Protein arginine N-methyltransferase 3
Type:
PROTEIN
Mol. Mass.:
59886.87
Organism:
Homo sapiens
Description:
ChEMBL_101368
Residue:
531
Sequence:
MCSLASGATGGRGAVENEEDLPELSDSGDEAAWEDEDDADLPHGKQQTPCLFCNRLFTSAEETFSHCKSEHQFNIDSMVHKHGLEFYGYIKLINFIRLKNPTVEYMNSIYNPVPWEKEEYLKPVLEDDLLLQFDVEDLYEPVSVPFSYPNGLSENTSVVEKLKHMEARALSAEAALARAREDLQKMKQFAQDFVMHTDVRTCSSSTSVIADLQEDEDGVYFSSYGHYGIHEEMLKDKIRTESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQAMDIIRLNKLEDTITLIKGKIEEVHLPVEKVDVIISEWMGYFLLFESMLDSVLYAKNKYLAKGGSVYPDICTISLVAVSDVNKHADRIAFWDDVYGFKMSCMKKAVIPEAVVEVLDPKTLISEPCGIKHIDCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNCHNRVVFSTGPQSTKTHWKQTVFLLEKPFSVKAGEALKGKVTVHKNKKDPRSLTVTLTLNNSTQTYGLQ
  
Inhibitor
Name:
BDBM50247363
Synonyms:
CHEMBL4082966
Type:
Small organic molecule
Emp. Form.:
C18H20N4O2
Mol. Mass.:
324.377
SMILES:
O=C(NCC(=O)N1C2CCC1CC2)Nc1ccc2cnccc2c1 |TLB:4:6:8.9:11.12|
Structure:
Search PDB for entries with ligand similarity: