Reaction Details  Report a problem with these data
Target
Renin
Ligand
BDBM50005303
Substrate
n/a
Meas. Tech.
ChEBML_195740
IC50
100±n/a nM
Citation
 Ocain, TD; Deininger, DD; Russo, R; Senko, NA; Katz, A; Kitzen, JM; Mitchell, R; Oshiro, G; Russo, A; Stupienski, R New modified heterocyclic phenylalanine derivatives. Incorporation into potent inhibitors of human renin. J Med Chem 35:823-32 (1992) [PubMed]
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50005303
Synonyms:
4-Cyclohexyl-2-hydroxy-3-{4-methyl-2-[2-(5-oxo-7H-imidazo[1,5-a]imidazol-6-yl)-3-phenyl-propionylamino]-pentanoylamino}-butyric acid isopropyl ester | CHEMBL354179
Type:
Small organic molecule
Emp. Form.:
C33H47N5O6
Mol. Mass.:
609.7562
SMILES:
CC(C)CC(NC(=O)[C@H](Cc1ccccc1)n1cc2[nH]ccn2c1=O)C(=O)N[C@@H](CC1CCCCC1)C(O)C(=O)OC(C)C
Structure:
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