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Target
Cytochrome P450 2C8
Ligand
BDBM50250181
Substrate
n/a
Meas. Tech.
ChEBML_1681251
IC50
>20000±n/a nM
Citation
 Dos Santos Fernandes, GF; de Souza, PC; Moreno-Viguri, E; Santivañez-Veliz, M; Paucar, R; Pérez-Silanes, S; Chegaev, K; Guglielmo, S; Lazzarato, L; Fruttero, R; Man Chin, C; da Silva, PB; Chorilli, M; Solcia, MC; Ribeiro, CM; Silva, CSP; Marino, LB; Bosquesi, PL; Hunt, DM; de Carvalho, LPS; de Souza Costa, CA; Cho, SH; Wang, Y; Franzblau, SG; Pavan, FR; Dos Santos, JL Design, Synthesis, and Characterization of N-Oxide-Containing Heterocycles with in Vivo Sterilizing Antitubercular Activity. J Med Chem 60:8647-8660 (2017) [PubMed]  Article
Target
Name:
Cytochrome P450 2C8
Synonyms:
CP2C8_HUMAN | CYP2C8 | CYPIIC8 | Cytochrome P450 2C8 (CYP2C8) | P450 IIC2 | P450 MP-12/MP-20 | P450 form 1 | S-mephenytoin 4-hydroxylase
Type:
Protein
Mol. Mass.:
55839.23
Organism:
Homo sapiens (Human)
Description:
P10632
Residue:
490
Sequence:
MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIPV
  
Inhibitor
Name:
BDBM50250181
Synonyms:
CHEMBL2338421 | N''-(5-Benzofuroxanylmethylidene)Isoniazide
Type:
Small organic molecule
Emp. Form.:
C13H9N5O3
Mol. Mass.:
283.2423
SMILES:
[O-][n+]1onc2ccc(\C=N\NC(=O)c3ccncc3)cc12
Structure:
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