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Target
Carbonic anhydrase 1
Ligand
BDBM10869
Substrate
n/a
Meas. Tech.
ChEBML_1685271
Ki
9300±n/a nM
Citation
 Del Prete, S; Vullo, D; Osman, SM; AlOthman, Z; Supuran, CT; Capasso, C Sulfonamide inhibition profiles of the?-carbonic anhydrase from the pathogenic bacterium Francisella tularensis responsible of the febrile illness tularemia. Bioorg Med Chem 25:3555-3561 (2017) [PubMed]  Article
Target
Name:
Carbonic anhydrase 1
Synonyms:
CA-I | CA1 | CAB | CAH1_HUMAN | Carbonate dehydratase I | Carbonic anhydrase | Carbonic anhydrase 1 (CA I) | Carbonic anhydrase 1 (CA-I) | Carbonic anhydrase 1 (Recombinant CA I) | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase B | Carbonic anhydrase I | Carbonic anhydrase I (CA I) | Carbonic anhydrase I (CA-I) | Carbonic anhydrase I (CAI) | Carbonic anhydrase I (hCA I) | Carbonic anhydrase isoenzyme I (hCA I) | hCA
Type:
Enzyme
Mol. Mass.:
28873.37
Organism:
Homo sapiens (Human)
Description:
P00915
Residue:
261
Sequence:
MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF
  
Inhibitor
Name:
BDBM10869
Synonyms:
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide | CHEMBL6753 | aromatic/heteroaromatic sulfonamide 14
Type:
Small organic molecule
Emp. Form.:
C3H6N4O2S2
Mol. Mass.:
194.235
SMILES:
Cn1nc(sc1=N)S(N)(=O)=O
Structure:
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