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Target
Vacuolar protein sorting-associated protein 35
Ligand
BDBM50253251
Substrate
n/a
Meas. Tech.
ChEBML_1685517
IC50
16000±n/a nM
Citation
 Barlaam, B; Cosulich, S; Fitzek, M; Germain, H; Green, S; Hanson, LL; Harris, CS; Hancox, U; Hudson, K; Lambert-van der Brempt, C; Lamorlette, M; Magnien, F; Ouvry, G; Page, K; Ruston, L; Ward, L; Delouvrié, B Discovery of a novel aminopyrazine series as selective PI3K? inhibitors. Bioorg Med Chem Lett 27:3030-3035 (2017) [PubMed]  Article
Target
Name:
Vacuolar protein sorting-associated protein 35
Synonyms:
MEM3 | MEM3 | Maternal-embryonic 3 | VPS35 | VPS35_HUMAN | Vacuolar protein sorting-associated protein 35 | Vesicle protein sorting 35 | hVPS35
Type:
PROTEIN
Mol. Mass.:
91688.33
Organism:
Homo sapiens
Description:
ChEMBL_105500
Residue:
796
Sequence:
MPTTQQSPQDEQEKLLDEAIQAVKVQSFQMKRCLDKNKLMDALKHASNMLGELRTSMLSPKSYYELYMAISDELHYLEVYLTDEFAKGRKVADLYELVQYAGNIIPRLYLLITVGVVYVKSFPQSRKDILKDLVEMCRGVQHPLRGLFLRNYLLQCTRNILPDEGEPTDEETTGDISDSMDFVLLNFAEMNKLWVRMQHQGHSRDREKRERERQELRILVGTNLVRLSQLEGVNVERYKQIVLTGILEQVVNCRDALAQEYLMECIIQVFPDEFHLQTLNPFLRACAELHQNVNVKNIIIALIDRLALFAHREDGPGIPADIKLFDIFSQQVATVIQSRQDMPSEDVVSLQVSLINLAMKCYPDRVDYVDKVLETTVEIFNKLNLEHIATSSAVSKELTRLLKIPVDTYNNILTVLKLKHFHPLFEYFDYESRKSMSCYVLSNVLDYNTEIVSQDQVDSIMNLVSTLIQDQPDQPVEDPDPEDFADEQSLVGRFIHLLRSEDPDQQYLILNTARKHFGAGGNQRIRFTLPPLVFAAYQLAFRYKENSKVDDKWEKKCQKIFSFAHQTISALIKAELAELPLRLFLQGALAAGEIGFENHETVAYEFMSQAFSLYEDEISDSKAQLAAITLIIGTFERMKCFSEENHEPLRTQCALAASKLLKKPDQGRAVSTCAHLFWSGRNTDKNGEELHGGKRVMECLKKALKIANQCMDPSLQVQLFIEILNRYIYFYEKENDAVTIQVLNQLIQKIREDLPNLESSEETEQINKHFHNTLEHLRLRRESPESEGPIYEGLIL
  
Inhibitor
Name:
BDBM50253251
Synonyms:
CHEMBL4072637
Type:
Small organic molecule
Emp. Form.:
C17H17N9O
Mol. Mass.:
363.3766
SMILES:
CNC(=O)c1nc(-c2nc(-c3cnc4ccccn34)c(C)nc2N)n(C)n1
Structure:
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