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Target
Trypanothione reductase
Ligand
BDBM50259698
Substrate
n/a
Meas. Tech.
ChEBML_1691709
Ki
282000±n/a nM
Citation
 Arias, DG; Herrera, FE; Garay, AS; Rodrigues, D; Forastieri, PS; Luna, LE; Bürgi, MD; Prieto, C; Iglesias, AA; Cravero, RM; Guerrero, SA Rational design of nitrofuran derivatives: Synthesis and valuation as inhibitors of Trypanosoma cruzi trypanothione reductase. Eur J Med Chem 125:1088-1097 (2017) [PubMed]  Article
Target
Name:
Trypanothione reductase
Synonyms:
N(1),N(8)-bis(glutathionyl)spermidine reductase | TPR | TR | TYTR_TRYCR
Type:
Homodimer; oxidoreductase
Mol. Mass.:
53868.26
Organism:
Trypanosoma cruzi
Description:
n/a
Residue:
492
Sequence:
MMSKIFDLVVIGAGSGGLEAAWNAATLYKKRVAVIDVQMVHGPPFFSALGGTCVNVGCVPKKLMVTGAQYMEHLRESAGFGWEFDRTTLRAEWKKLIAVKDEAVLNINKSYEEMFRDTEGLEFFLGWGSLESKNVVNVRESADPASAVKERLETENILLASGSWPHMPNIPGIEHCISSNEAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPKDGQVTLCYRGEMILRGFDHTLREELTKQLTANGIQILTKENPAKVELNADGSKSVTFESGKKMDFDLVMMAIGRSPRTKDLQLQNAGVMIKNGGVQVDEYSRTNVSNIYAIGDVTNRVMLTPVAINEAAALVDTVFGTNPRKTDHTRVASAVFSIPPIGTCGLIEEVASKRYEVVAVYLSSFTPLMHNISGSKYKTFVAKIITNHSDGTVLGVHLLGDNAPEIIQGVGICLKLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYVKGEKMEKPSEASL
  
Inhibitor
Name:
BDBM50259698
Synonyms:
CHEMBL4092991
Type:
Small organic molecule
Emp. Form.:
C10H12N2O4
Mol. Mass.:
224.2133
SMILES:
[O-][N+](=O)c1ccc(o1)C(=O)N1CCCCC1
Structure:
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