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Target
B-cell lymphoma 6 protein
Ligand
BDBM50260534
Substrate
n/a
Meas. Tech.
ChEMBL_1693999 (CHEMBL4044889)
IC50
212000±n/a nM
Citation
 Yasui, T; Yamamoto, T; Sakai, N; Asano, K; Takai, T; Yoshitomi, Y; Davis, M; Takagi, T; Sakamoto, K; Sogabe, S; Kamada, Y; Lane, W; Snell, G; Iwata, M; Goto, M; Inooka, H; Sakamoto, JI; Nakada, Y; Imaeda, Y Discovery of a novel B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor by utilizing structure-based drug design. Bioorg Med Chem 25:4876-4886 (2017) [PubMed]  Article
Target
Name:
B-cell lymphoma 6 protein
Synonyms:
B-cell lymphoma 5 protein | B-cell lymphoma 6 protein | BCL-5 | BCL-6 | BCL5 | BCL6 | BCL6_HUMAN | BCoR-BCL6 | LAZ3 | Protein LAZ-3 | ZBTB27 | ZNF51 | Zinc finger and BTB domain-containing protein 27 | Zinc finger protein 51
Type:
PROTEIN
Mol. Mass.:
78866.89
Organism:
Homo sapiens
Description:
ChEMBL_117695
Residue:
706
Sequence:
MASPADSCIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLDPEINPEGFCILLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKFIKASEAEMVSAIKPPREEFLNSRMLMPQDIMAYRGREVVENNLPLRSAPGCESRAFAPSLYSGLSTPPASYSMYSHLPVSSLLFSDEEFRDVRMPVANPFPKERALPCDSARPVPGEYSRPTLEVSPNVCHSNIYSPKETIPEEARSDMHYSVAEGLKPAAPSARNAPYFPCDKASKEEERPSSEDEIALHFEPPNAPLNRKGLVSPQSPQKSDCQPNSPTESCSSKNACILQASGSPPAKSPTDPKACNWKKYKFIVLNSLNQNAKPEGPEQAELGRLSPRAYTAPPACQPPMEPENLDLQSPTKLSASGEDSTIPQASRLNNIVNRSMTGSPRSSSESHSPLYMHPPKCTSCGSQSPQHAEMCLHTAGPTFPEEMGETQSEYSDSSCENGAFFCNECDCRFSEEASLKRHTLQTHSDKPYKCDRCQASFRYKGNLASHKTVHTGEKPYRCNICGAQFNRPANLKTHTRIHSGEKPYKCETCGARFVQVAHLRAHVLIHTGEKPYPCEICGTRFRHLQTLKSHLRIHTGEKPYHCEKCNLHFRHKSQLRLHLRQKHGAITNTKVQYRVSATDLPPELPKAC
  
Inhibitor
Name:
BDBM50260534
Synonyms:
CHEMBL4066375
Type:
Small organic molecule
Emp. Form.:
C15H9BrN2O6S2
Mol. Mass.:
457.276
SMILES:
OC(=O)CC(N1C(=S)S\C(C1=O)=C1/C(=O)Nc2ccc(Br)cc12)C(O)=O
Structure:
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