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Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM104572
Substrate
n/a
Meas. Tech.
ChEBML_1696510
IC50
8.8±n/a nM
Citation
 Bartolozzi, A; Abeywardane, A; Bosanac, T; Broadwater, JA; Chen, Z; Hutzler, JM; Huber, JD; Nemoto, P; Olague, A; Riether, D; Simpson, T; Takahashi, H; Wu, L; Zhang, Y; Zindell, RM Discovery and optimization of oxadiazole-based FLAP inhibitors. Bioorg Med Chem Lett 27:4652-4659 (2017) [PubMed]  Article
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Homo sapiens (Human)
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
  
Inhibitor
Name:
BDBM104572
Synonyms:
US8575201, 63
Type:
Small organic molecule
Emp. Form.:
C20H20N8O
Mol. Mass.:
388.4258
SMILES:
CCn1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Structure:
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