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Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM50261958
Substrate
n/a
Meas. Tech.
ChEBML_1696510
IC50
6.3±n/a nM
Citation
 Bartolozzi, A; Abeywardane, A; Bosanac, T; Broadwater, JA; Chen, Z; Hutzler, JM; Huber, JD; Nemoto, P; Olague, A; Riether, D; Simpson, T; Takahashi, H; Wu, L; Zhang, Y; Zindell, RM Discovery and optimization of oxadiazole-based FLAP inhibitors. Bioorg Med Chem Lett 27:4652-4659 (2017) [PubMed]  Article
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Homo sapiens (Human)
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
  
Inhibitor
Name:
BDBM50261958
Synonyms:
CHEMBL4096057
Type:
Small organic molecule
Emp. Form.:
C23H26N8O2
Mol. Mass.:
446.5049
SMILES:
CC(C)(O)Cn1cc(cn1)-c1nc(no1)[C@](C)(C1CC1)c1ccc(nc1)-c1cnc(N)nc1 |r|
Structure:
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