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Target
Kappa-type opioid receptor
Ligand
BDBM50265928
Substrate
n/a
Meas. Tech.
ChEMBL_1700353 (CHEMBL4051335)
EC50
>10000±n/a nM
Citation
 Sherwood, AM; Crowley, RS; Paton, KF; Biggerstaff, A; Neuenswander, B; Day, VW; Kivell, BM; Prisinzano, TE Addressing Structural Flexibility at the A-Ring on Salvinorin A: Discovery of a Potent Kappa-Opioid Agonist with Enhanced Metabolic Stability. J Med Chem 60:3866-3878 (2017) [PubMed]  Article
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM50265928
Synonyms:
CHEMBL4086641
Type:
Small organic molecule
Emp. Form.:
C21H24O7
Mol. Mass.:
388.4111
SMILES:
[H][C@@]12CC[C@@]3(C)[C@@H](CC(=O)C(O)=C3[C@@]1(C)C[C@H](OC2=O)c1ccoc1)C(=O)OC |r,c:11|
Structure:
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