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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM50266877
Substrate
n/a
Meas. Tech.
ChEMBL_1701465 (CHEMBL4052447)
Ki
21±n/a nM
Citation
 Twarda-Clapa, A; Krzanik, S; Kubica, K; Guzik, K; Labuzek, B; Neochoritis, CG; Khoury, K; Kowalska, K; Czub, M; Dubin, G; Dömling, A; Skalniak, L; Holak, TA 1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers. J Med Chem 60:4234-4244 (2017) [PubMed]  Article
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM50266877
Synonyms:
CHEMBL4098976
Type:
Small organic molecule
Emp. Form.:
C25H15ClF3N3O2
Mol. Mass.:
481.854
SMILES:
OC(=O)c1[nH]c2cc(Cl)ccc2c1-c1c(ncn1Cc1ccc(F)c(F)c1)-c1ccc(F)cc1 |(17.08,-16.49,;17.85,-15.17,;17.08,-13.82,;19.39,-15.17,;20.29,-16.42,;21.76,-15.92,;23.1,-16.69,;24.43,-15.92,;25.76,-16.69,;24.42,-14.37,;23.09,-13.61,;21.76,-14.39,;20.29,-13.91,;19.81,-12.44,;20.72,-11.21,;19.81,-9.96,;18.35,-10.43,;18.35,-11.98,;17.1,-12.89,;15.69,-12.26,;15.53,-10.73,;14.12,-10.11,;12.88,-11.01,;11.47,-10.39,;13.04,-12.55,;11.8,-13.45,;14.45,-13.17,;22.26,-11.21,;23.02,-12.55,;24.56,-12.55,;25.34,-11.22,;26.88,-11.22,;24.57,-9.88,;23.03,-9.88,)|
Structure:
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