Reaction Details  Report a problem with these data
Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM50266885
Substrate
n/a
Meas. Tech.
ChEMBL_1701465 (CHEMBL4052447)
Ki
17±n/a nM
Citation
 Twarda-Clapa, A; Krzanik, S; Kubica, K; Guzik, K; Labuzek, B; Neochoritis, CG; Khoury, K; Kowalska, K; Czub, M; Dubin, G; Dömling, A; Skalniak, L; Holak, TA 1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers. J Med Chem 60:4234-4244 (2017) [PubMed]  Article
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM50266885
Synonyms:
CHEMBL4077617
Type:
Small organic molecule
Emp. Form.:
C31H27Cl2FN4O3
Mol. Mass.:
593.475
SMILES:
Fc1ccc(cc1)-c1ncn(Cc2ccc(Cl)cc2)c1-c1c([nH]c2cc(Cl)ccc12)C(=O)OCCN1CCOCC1 |(30.21,-12.02,;28.67,-12.02,;27.9,-10.69,;26.36,-10.69,;25.59,-12.02,;26.36,-13.35,;27.9,-13.35,;24.05,-12.02,;23.14,-10.78,;21.68,-11.25,;21.68,-12.79,;20.43,-13.69,;19.02,-13.07,;17.78,-13.98,;16.37,-13.35,;16.21,-11.82,;14.8,-11.19,;17.45,-10.91,;18.86,-11.54,;23.14,-13.27,;23.61,-14.73,;22.71,-15.98,;23.61,-17.23,;25.08,-16.75,;26.41,-17.52,;27.75,-16.75,;29.08,-17.52,;27.75,-15.21,;26.41,-14.44,;25.08,-15.21,;21.17,-15.98,;20.4,-14.65,;20.4,-17.31,;18.86,-17.31,;18.09,-18.65,;16.55,-18.65,;15.78,-19.98,;14.24,-19.98,;13.47,-18.65,;14.24,-17.31,;15.78,-17.31,)|
Structure:
Search PDB for entries with ligand similarity: