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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM50266903
Substrate
n/a
Meas. Tech.
ChEMBL_1701465 (CHEMBL4052447)
Ki
225±n/a nM
Citation
 Twarda-Clapa, A; Krzanik, S; Kubica, K; Guzik, K; Labuzek, B; Neochoritis, CG; Khoury, K; Kowalska, K; Czub, M; Dubin, G; Dömling, A; Skalniak, L; Holak, TA 1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers. J Med Chem 60:4234-4244 (2017) [PubMed]  Article
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM50266903
Synonyms:
CHEMBL4096776
Type:
Small organic molecule
Emp. Form.:
C34H25Cl2FN4O3
Mol. Mass.:
627.492
SMILES:
COC(=O)c1ccc(CNC(=O)c2[nH]c3cc(Cl)ccc3c2-c2c(ncn2Cc2ccc(Cl)cc2)-c2ccc(F)cc2)cc1 |(12.14,-21.66,;12.91,-22.99,;14.45,-22.98,;15.23,-24.31,;15.22,-21.64,;14.44,-20.31,;15.21,-18.98,;16.75,-18.97,;17.51,-17.64,;19.04,-17.63,;19.81,-16.29,;19.03,-14.96,;21.35,-16.29,;22.26,-17.52,;23.72,-17.05,;25.06,-17.81,;26.39,-17.03,;27.72,-17.8,;26.37,-15.49,;25.04,-14.73,;23.71,-15.51,;22.25,-15.03,;21.76,-13.57,;22.67,-12.33,;21.75,-11.08,;20.29,-11.57,;20.3,-13.11,;19.06,-14.02,;17.65,-13.4,;16.41,-14.31,;15,-13.69,;14.83,-12.16,;13.42,-11.54,;16.07,-11.25,;17.48,-11.87,;24.2,-12.32,;24.96,-10.98,;26.5,-10.98,;27.28,-12.31,;28.82,-12.3,;26.51,-13.64,;24.98,-13.65,;17.52,-20.3,;16.76,-21.64,)|
Structure:
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