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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50267570
Substrate
n/a
Meas. Tech.
ChEMBL_1702992 (CHEMBL4054225)
IC50
460±n/a nM
Citation
 Shao, LD; Bao, Y; Shen, Y; Su, J; Leng, Y; Zhao, QS Synthesis of selective 11?-HSD1 inhibitors based on dammarane scaffold. Eur J Med Chem 135:324-338 (2017) [PubMed]  Article
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | 11beta-HSD1A | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_MOUSE | Hsd11 | Hsd11b1
Type:
Enzyme
Mol. Mass.:
32369.70
Organism:
Mus musculus (mouse)
Description:
P50172
Residue:
292
Sequence:
MAVMKNYLLPILVLFLAYYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNHITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMIAPYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEECALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMFVSN
  
Inhibitor
Name:
BDBM50267570
Synonyms:
CHEMBL4081242
Type:
Small organic molecule
Emp. Form.:
C15H24O3
Mol. Mass.:
252.3493
SMILES:
CC(C)[C@@H]1CC[C@H](C(O)=O)[C@]11CC=C(C)C(O)C1 |r,t:13|
Structure:
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