Reaction Details  Report a problem with these data
Target
Free fatty acid receptor 4
Ligand
BDBM50268539
Substrate
n/a
Meas. Tech.
ChEMBL_1705058 (CHEMBL4056291)
EC50
290±n/a nM
Citation
 Zhang, X; Cai, C; Winters, M; Wells, M; Wall, M; Lanter, J; Sui, Z; Ma, J; Novack, A; Nashashibi, I; Wang, Y; Yan, W; Suckow, A; Hua, H; Bell, A; Haug, P; Clapper, W; Jenkinson, C; Gunnet, J; Leonard, J; Murray, WV Design, synthesis and SAR of a novel series of heterocyclic phenylpropanoic acids as GPR120 agonists. Bioorg Med Chem Lett 27:3272-3278 (2017) [PubMed]  Article
Target
Name:
Free fatty acid receptor 4
Synonyms:
FFAR4 | FFAR4_HUMAN | G-protein coupled receptor 120 | G-protein coupled receptor 129 | G-protein coupled receptor GT01 | G-protein coupled receptor PGR4 | GPR120 | GPR129 | O3FAR1 | Omega-3 fatty acid receptor 1 | PGR4
Type:
PROTEIN
Mol. Mass.:
42256.91
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1508994
Residue:
377
Sequence:
MSPECARAAGDAPLRSLEQANRTRFPFFSDVKGDHRLVLAAVETTVLVLIFAVSLLGNVCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQTSEHLLDARAVVTHSEITKASRKRLTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLFFWVVAFTFANSALNPILYNMTLCRNEWKKIFCCFWFPEKGAILTDTSVKRNDLSIISG
  
Inhibitor
Name:
BDBM50268539
Synonyms:
CHEMBL4060663
Type:
Small organic molecule
Emp. Form.:
C20H12ClF6NO4
Mol. Mass.:
479.757
SMILES:
OC(=O)CCc1cc(F)c(OCc2c(noc2C(F)(F)F)-c2ccc(F)cc2Cl)c(F)c1
Structure:
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