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Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50012348
Substrate
n/a
Meas. Tech.
ChEMBL_138163 (CHEMBL748227)
Ki
18±n/a nM
Citation
 Karton, Y; Bradbury, BJ; Baumgold, J; Paek, R; Jacobson, KA Functionalized congener approach to muscarinic antagonists: analogues of pirenzepine. J Med Chem 34:2133-45 (1991) [PubMed]
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_RAT | Cholinergic, muscarinic M2 | Chrm-2 | Chrm2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51555.53
Organism:
RAT
Description:
P10980
Residue:
466
Sequence:
MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50012348
Synonyms:
2-(6-{4-[2-Oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-11-yl)-ethyl]-piperazin-1-yl}-hexyl)-isoindole-1,3-dione | CHEMBL66914
Type:
Small organic molecule
Emp. Form.:
C32H34N6O4
Mol. Mass.:
566.6502
SMILES:
O=C(CN1CCN(CCCCCCN2C(=O)c3ccccc3C2=O)CC1)N1c2ccccc2C(=O)Nc2cccnc12
Structure:
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