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Target
Urotensin-2 receptor
Ligand
BDBM50269946
Substrate
n/a
Meas. Tech.
ChEMBL_1707638 (CHEMBL4058871)
EC50
8.5±n/a nM
Citation
 Douchez, A; Billard, E; Hébert, TE; Chatenet, D; Lubell, WD Design, Synthesis, and Biological Assessment of Biased Allosteric Modulation of the Urotensin II Receptor Using Achiral 1,3,4-Benzotriazepin-2-one Turn Mimics. J Med Chem 60:9838-9859 (2017) [PubMed]  Article
Target
Name:
Urotensin-2 receptor
Synonyms:
G-protein coupled receptor 14 | GPR14 | UR-II-R | UR2R_HUMAN | UTS2R | Urotensin II receptor | Urotensin-II
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42159.71
Organism:
Homo sapiens (Human)
Description:
Urotensin-II UTS2R HUMAN::Q9UKP6
Residue:
389
Sequence:
MALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSAMGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKEWHFGDVGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLLTLPVMLAMRLVRRGPKSLCLPAWGPRAHRAYLTLLFATSIAGPGLLIGLLYARLARAYRRSQRASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLLAQYHQAPLAPRTARIVNYLTTCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLQPRARFQRCSGRSLSSCSPQPTDSLVLAPAAPARPAPEGPRAPA
  
Inhibitor
Name:
BDBM50269946
Synonyms:
CHEMBL4071437
Type:
Small organic molecule
Emp. Form.:
C34H35ClN4O2
Mol. Mass.:
567.12
SMILES:
Cl.COc1ccc(\C=C\C2=NN(CCCCN)C(=O)N(Cc3ccc(cc3)-c3ccccc3)c3ccccc23)cc1 |t:8|
Structure:
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