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Target
Renin
Ligand
BDBM50014053
Substrate
n/a
Meas. Tech.
ChEMBL_195939 (CHEMBL801665)
IC50
8.2±n/a nM
Citation
 Rosenberg, SH; Dellaria, JF; Kempf, DJ; Hutchins, CW; Woods, KW; Maki, RG; de Lara, E; Spina, KP; Stein, HH; Cohen, J Potent, low molecular weight renin inhibitors containing a C-terminal heterocycle: hydrogen bonding at the active site. J Med Chem 33:1582-90 (1990) [PubMed]
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50014053
Synonyms:
CHEMBL416429 | {1-[1-[1-Cyclohexylmethyl-2-hydroxy-2-(3-isopropyl-2-oxo-oxazolidin-5-yl)-ethylcarbamoyl]-2-(3H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester
Type:
Small organic molecule
Emp. Form.:
C35H52N6O7
Mol. Mass.:
668.8234
SMILES:
CC(C)N1C[C@H](OC1=O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C
Structure:
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