Reaction Details  Report a problem with these data
Target
Prostaglandin E2 receptor EP1 subtype
Ligand
BDBM50276250
Substrate
n/a
Meas. Tech.
ChEMBL_1715485 (CHEMBL4125534)
IC50
0.700000±n/a nM
Citation
 Atobe, M; Naganuma, K; Kawanishi, M; Hayashi, T; Suzuki, H; Nishida, M; Arai, H Discovery of a novel 2-(1H-pyrazolo[3,4-b]pyridin-1-yl)thiazole derivative as an EP Bioorg Med Chem Lett 28:2408-2412 (2018) [PubMed]  Article
Target
Name:
Prostaglandin E2 receptor EP1 subtype
Synonyms:
PE2R1_HUMAN | PGE receptor, EP1 subtype | PTGER1 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP1 subtype | Prostaglandin E2 receptor EP1 subtype (EP1) | Prostanoid EP1 receptor
Type:
Enzyme
Mol. Mass.:
41834.57
Organism:
Homo sapiens (Human)
Description:
P34995
Residue:
402
Sequence:
MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLRQLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF
  
Inhibitor
Name:
BDBM50276250
Synonyms:
CHEMBL4126319
Type:
Small organic molecule
Emp. Form.:
C17H12F3N3O3S
Mol. Mass.:
395.356
SMILES:
OC(=O)c1csc(n1)-n1nc(C2=CCCCO2)c2ccc(cc12)C(F)(F)F |t:12|
Structure:
Search PDB for entries with ligand similarity: