Reaction Details  Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50276841
Substrate
n/a
Meas. Tech.
ChEBML_1716851
IC50
447±n/a nM
Citation
 Teleb, M; Kuppast, B; Spyridaki, K; Liapakis, G; Fahmy, H Synthesis of 2-imino and 2-hydrazono thiazolo[4,5-d]pyrimidines as corticotropin releasing factor (CRF) antagonists. Eur J Med Chem 138:900-908 (2017) [PubMed]  Article
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
415
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50276841
Synonyms:
CHEMBL4161963
Type:
Small organic molecule
Emp. Form.:
C19H26N6S
Mol. Mass.:
370.515
SMILES:
CCN(CC)c1nc(C)nc2n(-c3c(C)cc(C)cc3C)\c(=N/N)sc12 |(3.83,-3.22,;3.84,-4.76,;5.17,-5.52,;6.5,-4.75,;6.5,-3.21,;5.18,-7.06,;3.85,-7.83,;3.85,-9.38,;2.51,-10.15,;5.18,-10.15,;6.52,-9.38,;8,-9.85,;7.99,-11.39,;6.64,-12.14,;5.32,-11.36,;6.63,-13.68,;7.96,-14.46,;7.95,-16,;9.3,-13.69,;9.31,-12.16,;10.65,-11.39,;8.9,-8.59,;10.44,-8.58,;11.22,-9.91,;7.98,-7.34,;6.51,-7.83,)|
Structure:
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