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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50277178
Substrate
n/a
Meas. Tech.
ChEBML_1717698
IC50
30±n/a nM
Citation
 Leiva, R; Griñan-Ferré, C; Seira, C; Valverde, E; McBride, A; Binnie, M; Pérez, B; Luque, FJ; Pallàs, M; Bidon-Chanal, A; Webster, SP; Vázquez, S Design, synthesis and in vivo study of novel pyrrolidine-based 11?-HSD1 inhibitors for age-related cognitive dysfunction. Eur J Med Chem 139:412-428 (2017) [PubMed]  Article
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM50277178
Synonyms:
CHEMBL4162610
Type:
Small organic molecule
Emp. Form.:
C18H27NO
Mol. Mass.:
273.4131
SMILES:
O=C(C1CCCCC1)N1CC2C(C1)C1CCC2C2CC12 |TLB:9:10:15.14:17.19,12:11:15.14:17.19,THB:18:17:15.14:10.11,18:19:15.14:10.11|
Structure:
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