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Target
P2X purinoceptor 7
Ligand
BDBM50277551
Substrate
n/a
Meas. Tech.
ChEMBL_1718144 (CHEMBL4133144)
IC50
37±n/a nM
Citation
 Gonzaga, DTG; Ferreira, LBG; Moreira Maramaldo Costa, TE; von Ranke, NL; Anastácio Furtado Pacheco, P; Sposito Simões, AP; Arruda, JC; Dantas, LP; de Freitas, HR; de Melo Reis, RA; Penido, C; Bello, ML; Castro, HC; Rodrigues, CR; Ferreira, VF; Faria, RX; da Silva, FC 1-Aryl-1H- and 2-aryl-2H-1,2,3-triazole derivatives blockade P2X7 receptor in vitro and inflammatory response in vivo. Eur J Med Chem 139:698-717 (2017) [PubMed]  Article
Target
Name:
P2X purinoceptor 7
Synonyms:
ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor
Type:
Protein
Mol. Mass.:
68602.85
Organism:
Homo sapiens (Human)
Description:
Q99572
Residue:
595
Sequence:
MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISSVHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCPEYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPALLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGDNFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYKENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSSNCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRSLQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCGSCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDSTNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
  
Inhibitor
Name:
BDBM50277551
Synonyms:
A-839977 | CHEMBL1628691
Type:
Small organic molecule
Emp. Form.:
C19H14Cl2N6O
Mol. Mass.:
413.26
SMILES:
Clc1cccc(c1Cl)-n1nnnc1NCc1ccccc1Oc1ccccn1
Structure:
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