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Target
Neutrophil elastase
Ligand
BDBM50278899
Substrate
n/a
Meas. Tech.
ChEMBL_1719626 (CHEMBL4134626)
Ki
3200±n/a nM
Citation
 Ryu, HW; Park, YJ; Lee, SU; Lee, S; Yuk, HJ; Seo, KH; Kim, YU; Hwang, BY; Oh, SR Potential Anti-inflammatory Effects of the Fruits of Paulownia tomentosa. J Nat Prod 80:2659-2665 (2017) [PubMed]  Article
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50278899
Synonyms:
CHEMBL4174694
Type:
Small organic molecule
Emp. Form.:
C26H30O7
Mol. Mass.:
454.5122
SMILES:
[#6]-[#8]-c1c(-[#8])cc(cc1-[#8])-[#6@@H]-1-[#6]-[#6](=O)-c2c(-[#8])c(-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](\[#6])-[#6])c(-[#8])cc2-[#8]-1 |r|
Structure:
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