Reaction Details  Report a problem with these data
Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM50278962
Substrate
n/a
Meas. Tech.
ChEMBL_1720265 (CHEMBL4135265)
Kd
548000±n/a nM
Citation
 Coletti, A; Camponeschi, F; Albini, E; Greco, FA; Maione, V; Custodi, C; Ianni, F; Grohmann, U; Orabona, C; Cantini, F; Macchiarulo, A Fragment-based approach to identify IDO1 inhibitor building blocks. Eur J Med Chem 141:169-177 (2017) [PubMed]  Article
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM50278962
Synonyms:
CHEMBL4176201
Type:
Small organic molecule
Emp. Form.:
C9H10FN3
Mol. Mass.:
179.1942
SMILES:
NCCc1nc2ccc(F)cc2[nH]1
Structure:
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