Reaction Details 
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Metabotropic glutamate receptor 6
Ligand
BDBM50280368
Substrate
n/a
Meas. Tech.
ChEMBL_1721721 (CHEMBL4136721)
EC50
>10000±n/a nM
Citation
Reed, CW; McGowan, KM; Spearing, PK; Stansley, BJ; Roenfanz, HF; Engers, DW; Rodriguez, AL; Engelberg, EM; Luscombe, VB; Loch, MT; Remke, DH; Rook, JM; Blobaum, AL; Conn, PJ; Niswender, CM; Lindsley, CW VU6010608, a Novel mGlu ACS Med Chem Lett 8:1326-1330 (2017) [PubMed] ArticleMore Info.:
Target
Name:
Metabotropic glutamate receptor 6
Synonyms:
GPRC1F | GRM6 | GRM6_HUMAN | MGLUR6 | Metabotropic glutamate receptor 6 | glutamate receptor, metabotropic 6 precursor | metabotropic glutamate 6
Type:
Enzyme Catalytic Domain
Mol. Mass.:
95479.26
Organism:
Homo sapiens (Human)
Description:
metabotropic glutamate 6 GRM6 HUMAN::O15303
Residue:
877
Sequence:
MARPRRAREPLLVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHARGAAGRACGQLKKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKATSTVAAPPKGEDAEAHK
Inhibitor
Name:
BDBM50280368
Synonyms:
CHEMBL4176971
Type:
Small organic molecule
Emp. Form.:
C18H15F3N4O4
Mol. Mass.:
408.3313
SMILES:
COc1ccc(cc1OC)C(=O)Nc1cc(OC(F)(F)F)ccc1-n1cncn1
Structure:
