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Target
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM50281168
Substrate
n/a
Meas. Tech.
ChEMBL_1722384 (CHEMBL4137384)
IC50
480±n/a nM
Citation
 Sainas, S; Pippione, AC; Lupino, E; Giorgis, M; Circosta, P; Gaidano, V; Goyal, P; Bonanni, D; Rolando, B; Cignetti, A; Ducime, A; Andersson, M; Järvå, M; Friemann, R; Piccinini, M; Ramondetti, C; Buccinnà, B; Al-Karadaghi, S; Boschi, D; Saglio, G; Lolli, ML Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors. J Med Chem 61:6034-6055 (2018) [PubMed]  Article
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN
Type:
Enzyme
Mol. Mass.:
42881.33
Organism:
Homo sapiens (Human)
Description:
Q02127
Residue:
395
Sequence:
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
  
Inhibitor
Name:
BDBM50281168
Synonyms:
CHEMBL4167855 | US20240034730, Compound 27
Type:
Small organic molecule
Emp. Form.:
C21H17N3O3
Mol. Mass.:
359.378
SMILES:
Cc1cc(NC(=O)c2c(O)nn3ccccc23)ccc1Oc1ccccc1
Structure:
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