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Target
Hyaluronidase-1/Hyaluronidase-2
Ligand
BDBM50292241
Substrate
n/a
Meas. Tech.
ChEMBL_1731707 (CHEMBL4147243)
IC50
465750±n/a nM
Citation
 Czarnecka, K; Chufarova, N; Halczuk, K; Maciejewska, K; Girek, M; Skibi?ski, R; Jo?czyk, J; Bajda, M; Kabzi?ski, J; Majsterek, I; Szyma?ski, P Tetrahydroacridine derivatives with dichloronicotinic acid moiety as attractive, multipotent agents for Alzheimer's disease treatment. Eur J Med Chem 145:760-769 (2018) [PubMed]  Article
Target
Name:
Hyaluronidase-1/Hyaluronidase-2
Synonyms:
Hyaluronidase
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 1731707
Components:
This complex has 2 components.
Component 1
Name:
Hyaluronidase-2
Synonyms:
3.2.1.35 | HYAL2 | HYAL2_BOVIN | Hyal-2 | Hyaluronidase-2 | Hyaluronoglucosaminidase-2
Type:
PROTEIN
Mol. Mass.:
53891.56
Organism:
Bos taurus
Description:
ChEMBL_116936
Residue:
473
Sequence:
MWTGLGPAVTLALVLVVAWATELKPTAPPIFTGRPFVVAWDVPTQDCGPRHKMPLDPKDMKAFDVQASPNEGFVNQNITIFYRDRLGMYPHFNSVGRSVHGGVPQNGSLWVHLEMLKGHVEHYIRTQEPAGLAVIDWEDWRPVWVRNWQDKDVYRRLSRHLVAIRHPDWPPERVAKEAQYEFEFAARQFMLETLRFVKAFRPRHLWGFYLFPDCYNHDYVQNWETYTGRCPDVEVSRNDQLAWLWAESTALFPSVYLEETLASSTHGRNFVSFRVQEALRVADVHHANHALPVYVFTRPTYSRGLTGLSEMDLISTIGESAALGAAGVILWGDAGFTTSNETCRRLKDYLTRSLVPYVVNVSWAAQYCSWAQCHGHGRCVRRDPNAHTFLHLSASSFRLVPSHAPDEPRLRPEGELSWADRNHLQMHFRCQCYLGWGGEQCQWDRRRAAGGASGAWAGSHLTGLLAVAVLAFT
  
Component 2
Name:
Hyaluronidase-1
Synonyms:
3.2.1.35 | HYAL1 | HYAL1_BOVIN | Hyal-1 | Hyaluronidase-1 | Hyaluronoglucosaminidase-1
Type:
PROTEIN
Mol. Mass.:
50513.67
Organism:
Bos taurus
Description:
ChEMBL_116936
Residue:
450
Sequence:
MRPFSLEVSLHLPWAMAAHLLPVCTLFLNLLSMTQGSRDPVVPNQPFTTIWNANTEWCMKKHGVDVDISIFDVVTNPGQTFRGPNMTIFYSSQLGTYPYYTSAGEPVFGGLPQNASLNAHLARTFQDILAAMPEPRFSGLAVIDWEAWRPRWAFNWDTKDIYRQRSRALVQKQHPDWLAPRVEAAAQDQFEGAAEEWMAGTLKLGQALRPQGLWGFYNFPECYNYDFKSPNYTGRCPLNICAQNDQLGWLWGQSRALYPSIYLPAALEGTKKTQMFVQHRVAEAFRVAAGAGDPKLPVLPYMQLFYDMTNHFLPAEELEHSLGESAAQGAAGVVLWVSWLSTSTKESCQAIKEYVDTTLGPSILNVTSGARLCSQVLCSGHGRCARRPSYPKARLILNSTSFSIKPTPGGGPLTLQGALSLEDRLRMAVEFECRCYRGWRGTRCEQWGMW
  
Inhibitor
Name:
BDBM50292241
Synonyms:
CHEMBL4159080
Type:
Small organic molecule
Emp. Form.:
C22H23Cl3N4O
Mol. Mass.:
465.803
SMILES:
Cl.Clc1cc(cnc1Cl)C(=O)NCCCNc1c2CCCCc2nc2ccccc12
Structure:
Search PDB for entries with ligand similarity: