Reaction Details  Report a problem with these data
Target
Sodium-dependent phosphate transporter 2
Ligand
BDBM50341384
Substrate
n/a
Meas. Tech.
ChEMBL_1734219 (CHEMBL4149755)
IC50
6200±n/a nM
Citation
 Filipski, KJ; Sammons, MF; Bhattacharya, SK; Panteleev, J; Brown, JA; Loria, PM; Boehm, M; Smith, AC; Shavnya, A; Conn, EL; Song, K; Weng, Y; Facemire, C; Jüppner, H; Clerin, V Discovery of Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1). ACS Med Chem Lett 9:440-445 (2018) [PubMed]  Article
Target
Name:
Sodium-dependent phosphate transporter 2
Synonyms:
GLVR-2 | GLVR2 | Gibbon ape leukemia virus receptor 2 | PIT2 | Phosphate transporter 2 | PiT-2 | S20A2_HUMAN | SLC20A2 | Sodium-dependent phosphate transporter 2 | Solute carrier family 20 member 2 | hPit2
Type:
PROTEIN
Mol. Mass.:
70391.57
Organism:
Homo sapiens
Description:
ChEMBL_118051
Residue:
652
Sequence:
MAMDEYLWMVILGFIIAFILAFSVGANDVANSFGTAVGSGVVTLRQACILASIFETTGSVLLGAKVGETIRKGIIDVNLYNETVETLMAGEVSAMVGSAVWQLIASFLRLPISGTHCIVGSTIGFSLVAIGTKGVQWMELVKIVASWFISPLLSGFMSGLLFVLIRIFILKKEDPVPNGLRALPVFYAATIAINVFSIMYTGAPVLGLVLPMWAIALISFGVALLFAFFVWLFVCPWMRRKITGKLQKEGALSRVSDESLSKVQEAESPVFKELPGAKANDDSTIPLTGAAGETLGTSEGTSAGSHPRAAYGRALSMTHGSVKSPISNGTFGFDGHTRSDGHVYHTVHKDSGLYKDLLHKIHIDRGPEEKPAQESNYRLLRRNNSYTCYTAAICGLPVHATFRAADSSAPEDSEKLVGDTVSYSKKRLRYDSYSSYCNAVAEAEIEAEEGGVEMKLASELADPDQPREDPAEEEKEEKDAPEVHLLFHFLQVLTACFGSFAHGGNDVSNAIGPLVALWLIYKQGGVTQEAATPVWLLFYGGVGICTGLWVWGRRVIQTMGKDLTPITPSSGFTIELASAFTVVIASNIGLPVSTTHCKVGSVVAVGWIRSRKAVDWRLFRNIFVAWFVTVPVAGLFSAAVMALLMYGILPYV
  
Inhibitor
Name:
BDBM50341384
Synonyms:
CHEMBL4170023
Type:
Small organic molecule
Emp. Form.:
C21H16ClF3N2O4S
Mol. Mass.:
484.876
SMILES:
COc1ccc(NS(=O)(=O)c2cccc(c2)C(F)(F)F)c(c1)C(=O)Nc1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: