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Target
Phospholipase A2 group V
Ligand
BDBM50366784
Substrate
n/a
Meas. Tech.
ChEMBL_1735581 (CHEMBL4151117)
IC50
2230±n/a nM
Citation
 Knerr, L; Giordanetto, F; Nordberg, P; Pettersen, D; Selmi, N; Beisel, HG; de la Motte, H; Olsson, T; Perkins, TDJ; Herslöf, M; Månsson, Å; Dahlström, M; Starke, I; Broddefalk, J; Saarinen, G; Klingegård, F; Hurt-Camejo, E; Rosengren, B; Brengdahl, J; Jansen, F; Rohman, M; Sandmark, J; Hallberg, K; Åkerud, T; Roth, RG; Ahlqvist, M Discovery of a Series of Indole-2 Carboxamides as Selective Secreted Phospholipase A ACS Med Chem Lett 9:594-599 (2018) [PubMed]  Article
Target
Name:
Phospholipase A2 group V
Synonyms:
PA2G5_HUMAN | PLA2G5 | Phospholipase A2 group V | Secretory phospholipase A2, group V (sPLA2-V)
Type:
Protein
Mol. Mass.:
15682.61
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
138
Sequence:
MKGLLPLAWFLACSVPAVQGGLLDLKSMIEKVTGKNALTNYGFYGCYCGWGGRGTPKDGTDWCCWAHDHCYGRLEEKGCNIRTQSYKYRFAWGVVTCEPGPFCHVNLCACDRKLVYCLKRNLRSYNPQYQYFPNILCS
  
Inhibitor
Name:
BDBM50366784
Synonyms:
CHEMBL4171084
Type:
Small organic molecule
Emp. Form.:
C19H15F3N2O4
Mol. Mass.:
392.3286
SMILES:
NC(=O)c1cc2ccc(OC(F)(F)F)cc2n1-c1cccc(CCC(O)=O)c1
Structure:
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